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Notice of Special Interest (NOSI): Development of Organotypic Culture Models for Transplantation Immunology Research
This Notice of Special Interest (NOSI) encourages applications that focus on the development and validation of tissue-, stem-, or progenitor-cell-derived “3D” organotypic culture models (OCM) for transplantation immunology research.
OCM offer several advantages over traditional 2D cell cultures including improved modeling of tissue architecture, cell-cell interactions, and other microenvironmental aspects of tissues and organ systems. To that end, kidney, lung, liver, intestinal, pancreatic islet, spleen, and lymph node organoids are being developed for or are currently used in experimental regenerative medicine applications as well as cancer, autoimmune, and infectious disease research.
Recent developments in OCM are extending the potential utility of these models to investigate complex immunological systems in vitro. Microphysiological systems (MPS) with multiple microfluidic chambers can be used to control differentiation of organoids under mitogen gradients, promote organoid vascularization, and model organ-organ interactions. Technological advancements in biofabrication and 3D printing can generate complex scaffold structures representative of organs with improved reproducibility and scalability. The development of non-immunogenic synthetic or de-cellularized matrices to support organoid formation is another active area of research. This NOSI aims to leverage recent advances in OCM to promote the development of these tools for transplantation immunology research.
This notice applies to due dates on or after February 5, 2024 and subsequent receipt dates through November 16, 2026 .
NOT-AI-23-064
Specialties
Eligibility Requirements
Sponsor Details
Sponsor Institute/Organizations: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Grant
Final Deadline:
Oct 05, 2024
Funding Amount:
Varies
This program has not been verified by Trialect.
Host Details
Affiliation: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.
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