The mission of the NIH is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The NIH is committed to supporting research that will increase scientific understanding of health and well-being and lead to the development of effective evidence-based strategies, interventions, and services for people of all ages and backgrounds. NIH places a high priority on research with individuals and populations at increased risk for adverse health outcomes, and especially those who have received insufficient attention from the scientific research enterprise. To this end, and in response to Executive Order 14075 on Advancing Equality for Lesbian, Gay, Bisexual, Transgender, Queer, and Intersex Individuals, this Notice of Special Interest (NOSI) announces an interest in research on the impact and consequences of family support and family rejection on the health and well-being of sexual and gender minority (SGM, defined for NIH purposes in NOT-OD-19-139 ) individuals across the life course.
Family structure and composition have changed over the past several decades owing to a variety of factors, including lower rates of marriage and fertility, increased rates of divorce and cohabitation, the separation of marriage from child-raising, and growth in one-person households, as well as multigenerational and extended families. At the same time, the prevalence of other ties, such as step-kin and non-marital romantic partners, is increasing. These developments have expanded what is considered a family in modern times.
Researchers may define families, support, and rejection differently; thus, applications should clearly define these terms within the context of the proposed research.
The goal of this NOSI is to boost research on the impact and consequences of family rejection and family support on the health and well-being of SGM persons across the life course. Research proposed under this NOSI may include behavioral, social, clinical, implementation, basic, complementary, integrative, and any other relevant research approaches that probe the influences of family rejection, acceptance, affirmation, support, and belonging on the immediate and long-term health and health outcomes of SGM individuals at any life stage. Studies may also include prevention, intervention, and service delivery research that seeks to prevent, reduce, or treat adverse effects associated with family rejection and/or improve or maintain SGM people’s health.
NOT-OD-23-166
Expiration Date: May 08, 2026
Applications focusing on a non-responsive topic, that reference a NOFO beyond those listed in this NOSI, or that are otherwise nonresponsive to the terms of this NOSI will be withdrawn from consideration for this initiative.
Sponsor Institute/Organizations: National Institutes of Health
Sponsor Type:
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
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May 08, 2026
May 08, 2026
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Affiliation: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Website URL: https://grants.nih.gov/grants/guide/notice-files/NOT-AA-24-007.html
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