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Notice of Intent to Publish a Funding Opportunity Announcement for Complement-ARIE New Approach Methodologies (NAMs) Technology Development Centers (UM1 Clinical Trial Optional)

National Institutes of Health

Note: This is a Forecasted Opportunity.

The purpose of this Notice is to inform the research community that the NIH Common Fund, along with its partner NIH Institutes, Centers, and Offices, is planning to issue a Notice of funding opportunity (NOFO) to support the Complement Animal Research In Experimentation (Complement-ARIE) program. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

The NIH Common Fund’s Complement Animal Research In Experimentation (Complement-ARIE) program goal is to accelerate the development, standardization, validation, and use of human-based New Approach Methodologies (NAMs).

NAMs, are laboratory (in vitro and in chemico) or computer-based (in silico) research approaches intended to more accurately model human biology, and complement, or in some cases, replace traditional research models. The Complement-ARIE program will build upon ongoing efforts in the field related to NAMs, while identifying opportunities for innovation and coordination amongst the various interest groups, including the Advisory Committee to the Director (ACD) on catalyzing the development and use of Novel Alternative Methods to Advance Biomedical Research . The ACD working group recommendations are aligned with Complement-ARIE program goals. Feedback from the scientific community was solicited through the Complement-ARIE Challenge to propel the development and refinement of human-based NAMs. These Common Fund strategic planning activities have guided the development of the Complement-ARIE program.

Complement-ARIE is expected to significantly advance understanding of human health and disease by providing a range of mature and/or validated and standardized biomedical research models. Developing these models will require multi-disciplinary expertise in in vitro, in silico and in chemico approaches focused on modeling and understanding human diseases and conditions, personalized medicine, environmental science, and in screening therapeutics for safety and effectiveness and environmental compounds for health hazards.

The overarching goal of the Complement-ARIE program is to catalyze the development, standardization, validation, and use of human-based NAMs that will transform the way we do basic, translational, and clinical sciences. The program goals include:

Better model and understand human health and disease outcomes across diverse populations.
Develop NAMs that provide insight into specific biological processes or disease states.
Validate mature NAMs to support regulatory use and standardization.
Complement traditional models and make biomedical research more efficient and effective.

Estimated Post Date:

Oct 18, 2024

Estimated Application Due Date:

Feb 28, 2025

Specialties

Interdisciplinary

Medical - Basic Science

Medical - Translational

Medical

Medical - Clinical Science

Eligibility Requirements

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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