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NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)

National Institutes of Health

The purpose of the NHLBI Emerging Investigator Award (EIA) is to promote scientific productivity and innovation by providing long-term support and increased flexibility to experienced Program Directors/Principal Investigators (PDs/PIs) who are currently PDs/PIs on at least two NHLBI R01-equivalent awards (of which one must be an NHLBI-funded NIH Early Stage Investigator (ESI) award) and whose outstanding record of research demonstrate their ability to make major contributions to the heart, lung, blood and sleep (HLBS) research. The EIA is intended to support an investigator's research program, rather than a research project, by providing the primary and most likely sole source of NHLBI funding on individual grant awards.

The EIA will support the research program of NHLBI-funded investigators for up to seven years and will provide increased freedom to conduct research that breaks new ground or extends previous discoveries in new directions. It will also allow PDs/PIs to take greater risks and to pursue research that requires a longer time frame. Research supported by the EIA must be within the scope of the NHLBI mission .

It is anticipated that the EIA will:

Provide a stable funding environment, thereby improving productivity and facilitating ambitious and creative research;
Accelerate scientific innovation by enabling flexibility in pursuing new research directions as they arise, since PD/PIs will not be bound to specific aims proposed in advance of the studies;
Reduce the time researchers spend writing grant applications and managing multiple grant awards, thereby allowing more time to be devoted to conducting research;
Facilitate the commitment of the PDs/PIs to research through increased stability of funding; and
Enable PDs/PIs to devote more time and energy to mentoring students and junior scientists and providing scientific service.

Deadlines:

Letter of Intent Due Date(s): 30 days prior to the application due date
Application Due Date(s): Feb 19, 2025; Feb 19, 2026; Feb 19, 2027
AIDS Application Due Date(s): April 28, 2025; April 28, 2026; April 28, 2027

RFA-HL-26-003 Expiration Date April 29, 2027

Specialties

Medical

Medical - Clinical Science

Medical - Basic Science

Medical - Translational

Eligibility Requirements

Only single PD/PI applications are allowed. Applications with multiple PDs/PIs will not be accepted. Applications that do not meet eligibility requirements will not be reviewed.

Eligibility is determined by NHLBI after the receipt of applications on the intended application due date. Eligibility to apply to this NOFO is limited to PDs/PIs who meet all of the following criteria:

Are currently PD/PI on at least two NHLBI R01-equivalent (defined here as R01, DP1, or DP2) awards.
- At least one of the R01-equivalent awards must meet all the following requirements :
  - Be a single-PD/PI award, AND
  - Not be in a no-cost extension (NCE), AND
  - Not be an NIH-defined clinical trial, unless that clinical trial meets the definition of a mechanistic clinical trial or a BESH trial, as defined in Section I of this NOFO.
- The additional qualifying R01-equivalent(s) can be multiple-PD/PI, and/or in a first NCE, and/or an NIH-defined clinical trial.
- One of the awards must be an NHLBI-funded NIH Early Stage Investigator (ESI) R01.
The PD/PI must commit a minimum of six person months (i.e., the equivalent of 50% effort on a full-year appointment, 66.67% on a 9-month appointment, or 100% on a 6-month appointment) throughout the duration of the EIA.

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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