This Notice of Funding Opportunity (NOFO) supports studies proposing to utilize methodologies for in-cell structural biology to address the mechanistic insights and causal cellular and molecular relationships between molecular pathology and Alzheimer’s disease-related dementias (ADRD) clinical phenotypic outcomes. The applications are expected to focus on determining structures of ADRD-linked macromolecular in native (healthy and pathological) settings. The proposed methodology is expected to provide high-resolution information on the identity, dynamics and relative abundance of macromolecular species associated with ADRD and how pathological environments influence dynamics and structural conformations. Studies in response to this NOFO can also include the development of in situ research tools and resources to further characterize and validate the structural findings. The long-term goal of this funding opportunity is for these structural studies in the native cellular environment to inform efficient tools development and designs that better identify and monitor the accumulation of dysfunctional proteins in patients, as well as for other diagnostic, treatment response, therapeutic development and other related applications.
Application Due Date: Oct. 4, 2024
PAR-24-234 Expiration Date October 05, 2024
Sponsor Institute/Organizations: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Oct 04, 2024
$2,500,000
Affiliation: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.