The goal of this Notice of Funding Opportunity (NOFO) is to examine mechanisms of reciprocal interactions between HIV-associated neuroinflammation and central nervous system (CNS) HIV persistence. In particular this NOFO encourages research focused on defining the role and mechanisms of defective proviruses, HIV proteins and/or nucleic acids in inducing inflammation, immune activation and CNS co-morbidities. The impact of neuroinflammation in regulating CNS reservoir dynamics is also an area of interest. Novel therapeutic strategies targeting the reciprocal impact of persistent virus and associated neuroinflammation in the CNS compartment is also an area of high priority for this initiative. State-of-the-art CNS cell systems, organoid models, post-mortem tissue, animal models and single-cell technologies can be used as potential tools to address this research area. Basic and Translational research in domestic and international settings are also of interest. Multidisciplinary research teams and collaborations are encouraged but not required. High risk/high payoff projects that lack preliminary data may be most appropriate for the companion R21 NOFO, RFA-MH-25-181 while applicants with preliminary data may wish to apply using this R01 mechanism.
Deadlines:
RFA-MH-25-180 Expiration Date November 09, 2024
Sponsor Institute/Organizations: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Nov 08, 2024
LOI Deadline: October 8th, 2024
Varies
Affiliation: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Disclaimer:It is mandatory that all applicants carry workplace liability insurance, e.g., https://www.protrip-world-liability.com (Erasmus students use this package and typically costs around 5 € per month - please check) in addition to health insurance when you join any of the onsite Trialect partnered fellowships.