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Maximizing Investigators Research Award (MIRA) for Early Stage Investigators (ESI) (R35 - Clinical Trial Optional)

National Institutes of Health

The Maximizing Investigators' Research Award (MIRA) under this Notice of Funding Opportunity (NOFO) provides support for a program of research in an early stage investigator's laboratory that falls within the mission of NIGMS. For the purpose of this NOFO, a program of research is a collection of projects in the investigator's lab that are relevant to the mission of NIGMS . The goal of MIRA is to increase the efficiency and efficacy of NIGMS funding.

Application Due Date(s): October 3, 2023; Feb 1, 2024; Oct 3, 2024; Feb 3, 2025; Oct 3, 2025; Feb 3, 2026

PAR-23-145 Expiration Date February 04, 2026

Specialties

Medical

Medical - Clinical Science

Medical - Basic Science

Medical - Translational

Eligibility Requirements

For this NOFO, eligibility is limited to NIH-defined Early Stage Investigators . ESI eligibility is determined at the time the application is submitted. Any individual with the skills, knowledge, and resources necessary to carry out the proposed research as the PD/PI is invited to work with their organization to develop an application for support. Women, individuals from underrepresented racial and ethnic groups, from disadvantaged backgrounds, or with disabilities ( NOT-OD-22-019 ) are always encouraged to apply for NIH support.

Applications from investigators who are not eligible to receive the award will be administratively withdrawn without review. Note that ESI status can be extended beyond the normal 10-year window after completion of the terminal research degree or medical residency for certain life or career events, as described in NOT-OD-19-125 and on the NIH website . This NOFO does not allow resubmissions, although a new application can be submitted after an unsuccessful attempt as long as the PD/PI remains eligible, as defined above.

PDs/PIs who are currently New Investigators proposing research within the scientific mission of NIGMS are not eligible for this NOFO and should apply instead through PAR-22-180 or its subsequent reissuance.

The PD/PI is required to devote at least 51% of their total research effort to this award. The total research effort should include the PD/PI's combined research effort at all institutions where the PD/PI holds an appointment, should be expressed in person-months, and should not include time expended toward teaching or administration not directly related to the PD's/PI's research, and/or clinical duties. NIGMS staff will verify that the MIRA research effort requirement is met by using the Other support documentation and will exclude support for which the purpose is education, training or enhancing workforce diversity.

Only single PD/PI applications are allowed. Applications with multiple PDs/PIs will not be accepted.

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

A PD/PI may submit an R01 application and a MIRA application within the same council round. If both applications are deemed meritorious enough for funding, NIGMS will only award one of the two grants and applicants will be required to withdraw the other.

PDs/PIs who submitted a MIRA application in previous years and are still eligible for this NOFO (i.e., retain their ESI status ) are welcome to apply, but must submit a New application because Resubmission applications are not allowed.