The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American populations. This includes 1) etiologic research that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests interventions for health promotion, prevention, treatment, or recovery, and 3) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to identify and rigorously test culturally appropriate solutions to reduce morbidity and mortality. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. This NOFO is part of the Intervention Research to Improve Native American Health (IRINAH) initiative, which also includes NOFOs using the R21 Exploratory/Developmental Research Grant mechanism ( PAR-25-380 ) and the R34 Clinical Trial Planning Grant mechanism ( PAR-25-378 ). Research projects may address topics within the identified interests of any of the participating Institutes or Centers; projects are not limited to substance use and addiction research.
For the purposes of this NOFO, Native Americans include the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. mainland border), and Native Hawaiians. The term ‘Native Hawaiian’ means any individual any of whose ancestors were natives, prior to 1778, of the area which now comprises the State of Hawaii.
Deadlines:
PAR-25-379 Expiration Date January 08, 2027
Eligible Organizations
Higher Education Institutions
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
Nonprofits Other Than Institutions of Higher Education
For-Profit Organizations
Local Governments
Federal Government
Other
Foreign Organizations
Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Eligible Countries:
Sponsor Institute/Organizations: National Institutes of Health
Sponsor Type:
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
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Oct 21, 2025
Oct 21, 2025
$450,000
Affiliation: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Website URL: https://grants.nih.gov/grants/guide/notice-files/NOT-AA-24-007.html
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