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Funding Opportunity Announcement for Impact of Environmental Exposures on Gut-Brain Signaling in Neurological Conditions (R01)

National Institutes of Health

Note: This is a Forecasted Opportunity.

The National Institute of Environmental Health Sciences (NIEHS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research that builds on our understanding of the gut microbiome-brain axis for the purpose of identifying improved detection, prevention, and intervention strategies for environmental exposure-induced neurological diseases. Given the overlapping gut-brain signaling pathways and the prevalence of neurological conditions with gut-related comorbidities, the scope of this program would be inclusive of a wide range of neurological outcomes, including mental health disorders and chronic neurodegenerative conditions such as Parkinson’s disease and Alzheimer’s disease. The objective of this program is to develop gut-focused intervention strategies (e.g., probiotics, microbial biomarkers, nutritional supplements and novel therapeutics) to decrease risk, slow progression, or possibly reverse these neurological condition(s).

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into this area of biological mechanisms underlying the effects of environmental exposures on neurological outcomes and the mediating role of the gut-brain axis are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in toxicology, microbiome, and neuroscience will be encouraged and these investigators should also begin considering applying for this application.

Estimated Post Date:

Oct 27, 2025

Estimated Application Due Date:

Jan 15, 2026

Specialties

Interdisciplinary

Medical - Basic Science

Medical - Translational

Medical

Medical - Clinical Science

Eligibility Requirements

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Sponsor Type: Government/Federal

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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