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Dear Colleague Letter: Tool Development for Molecular and Cell Biology (Tools4Cells)

National Science Foundation

Dear Colleagues:

Opening new frontiers in molecular and cellular biosciences depends heavily on technological innovation; therefore, continued development of new tools and methods is critical, especially using interdisciplinary approaches that leverage advances in other fields of research. Technological breakthroughs have had a profound and catalytic influence on molecular and cell biology – through application of existing tools to study molecular and cellular processes in new and creative ways, or through development of novel tools to study areas that were previously inaccessible. Recent examples include novel gene-editing technologies; single-cell multi-omics; single-cell and single-molecule imaging of dynamic processes; cryo-EM and x-ray free electron lasers to study macromolecular dynamics at atomic resolution; and molecular dynamics simulations at increasing spatiotemporal scales and complexity.

The purpose of this Dear Colleague Letter (DCL) is to encourage submission of proposals to develop novel tools and methods that improve scientists’ abilities to measure, analyze, manipulate, or control critical aspects of cellular properties and functions in order to continue to push boundaries and open new avenues of inquiry in molecular and cellular biosciences.

Proposals responsive to this DCL should be submitted as follows based on the above criteria:

Division of Molecular and Cellular Biosciences via full proposals to any program in the MCB core solicitation (currently NSF 23-548 ). As an alternate to full proposals, for exploratory projects that are "high-risk/high-payoff", investigators should consider the EArly-concept Grants for Exploratory Research (EAGER) type of proposal for up to $300,000 (including indirect costs) over two years. Specific instructions for preparation and submission of EAGER proposals can be found in Chapter II.F.3 of the NSF Proposal and Award Policies and Procedures Guide (PAPPG; currently NSF 23-1 ). For EAGER inquiries, please submit a Concept Outline of the proposed work to the NSF Program Suitability & Proposal Concept Tool at https://suitability.nsf.gov . Be sure to select the Molecular and Cellular Biosciences Division as the relevant NSF unit.

Division of Biological Infrastructure via proposals to the Infrastructure Innovation for Biological Research (Innovation) Program via the IIBR solicitation (currently NSF 23-578 ).

The title of any proposal submitted to either division in response to this DCL should begin with "Tools4Cells:". Proposals may be submitted at any time.

Specialties

Environmental & Life Sciences

Medical - Basic Science

Medical

Eligibility Requirements

Sponsor Details

Sponsor Institute/Organizations: National Science Foundation

Sponsor Type:

Address: National Science Foundation Alexandria, VA 22314

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