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Dear Colleague Letter: Leveraging Innovations From Evolution (LIFE)

National Science Foundation

January 17, 2024

Dear Colleagues:

The Directorate for Biological Sciences (BIO) of the National Science Foundation (NSF) encourages submission of proposals focusing on Leveraging Innovations From Evolution (LIFE).

Over the history of life on Earth, organisms have repeatedly evolved innovative adaptive traits in response to diverse biotic and abiotic pressures. Convergent evolution refers to cases where analogous traits arise independently in separate lineages, often as a response to similar selective pressures. This comparative framework is valuable for robustly exploring the origins, mechanisms, and macro-evolution of life's innovations. Due to the explosive growth of a) high-quality reference genomes from diverse organisms, b) new methodological and computational advances (e.g., application of generative artificial intelligence to protein structural modeling and synthetic biology), c) the extended research utility of biological collections, and d) deep organismal and more complete phylogenetic knowledge of species across the entire tree of life, scientists are now poised to collaboratively discover the underpinnings of nature-based solutions to life's common problems. NSF BIO seeks to speed discovery and understanding of biological innovations that hold significant potential for applications in the bioeconomy, including industrial processes, pharmaceuticals, agriculture, energy production, nature-based solutions to climate change, and planetary sustainability and resilience.

The unprecedented and myriad environmental challenges that confront human society today require bold actions and new research paradigms. In Executive Order 14081 (Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe, and Secure American Bioeconomy), the White House directed federal agencies to foster innovative solutions to climate change, food and agriculture security, human health, and sustainable technologies through the use of new data, predictive models, and products gleaned from discoveries originating from the study of diverse organisms across the tree of life. With this DCL, the NSF seeks to catalyze research that leverages the full diversity and complexity of life to focus attention on the discovery of molecular and evolutionary mechanisms that have permitted organisms, over millions of years of evolution, to innovate and thrive, often in hostile and changing environments. By Leveraging Innovations From Evolution (LIFE), and bolstering computational tools and resources (e.g., biobanks, databases, and algorithms), NSF BIO seeks to speed discoveries of nature-based solutions that will benefit science and society.

Proposals responsive to this DCL should be submitted to one of the following programs, and Principal Investigators (PIs) are strongly encouraged to reach out to a cognizant Program Officer (PO) to discuss the topic before submission.

Integrative Research in Biology (IntBIO) track, or directly to the core solicitation in any of the following divisions:
- Division of Environmental Biology (currently NSF 23-549 )
- Division of Molecular and Cellular Biosciences (currently NSF 23-548 )
- Division of Integrative Organismal Systems (currently NSF 23-547 )
Infrastructure Innovation for Biological Research program (currently NSF 23-578 )

Specialties

Environmental & Life Sciences

Medical - Basic Science

Medical

Eligibility Requirements

Sponsor Details

Sponsor Institute/Organizations: National Science Foundation

Sponsor Type:

Address: National Science Foundation Alexandria, VA 22314

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