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CARE: Cutting Alzheimers Risk through Endocrinology

Wellcome Leap

Worldwide, someone develops Alzheimer’s disease every 3.2 seconds. Nearly two-thirds of all patients are women.

CARE aims to cut the lifetime risk of Alzheimer’s among women by half, reducing risk for 330 million women globally – and, given current conversion rates, preventing 54.5 million Alzheimer’s cases by 2050.

CARE is focused on women, beginning in midlife, when the potential for preventing Alzheimer’s is greatest. Deep phenotypic identification of female-specific risks, coupled with rapid stratification and patient-specific matching to the most promising treatment options, has the potential to cut Alzheimer’s risk in the female population in half. In the United States alone, this would result in $4.56 trillion USD in savings. The global implications would be multiples of this number. Therefore, the program will also emphasize advances that increase access and reduce cost.

Our ultimate goal is to cut women’s lifetime risk of Alzheimer’s in half. CARE is focused on the intersection of neuroendocrine risks and neurodegeneration so as to identify personalized preventative strategies and treatments. This approach utilizes an individualized medicine framework — leveraging biomarkers, advanced imaging, genetic profiling— to tailor interventions to the specific needs of women at risk for Alzheimer’s due to neuroendocrine aging.

Potential applicants at Duke should consult with Steve Murray, Assoc. Director, Foundation Relations ( stephen.murray@duke.edu ) before applying.

Deadline for Abstracts: March 14, 2025

Specialties

Bioinformatics

Immunology

Neurosurgery

Data Science

Neurosciences

Technology Development

Eligibility Requirements

Performers from universities and research institutions: small, medium, and large companies (including venture-backed); and government or non-profit research organizations are invited to propose.

Sponsor Details

Sponsor Institute/Organizations: Wellcome Leap

Sponsor Type:

Address: Wellcome Leap , San Diego, California

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