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BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)

National Institutes of Health

This Notice of Funding Opportunity (NOFO) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support facilities at Resource-Limited Institutions (RLIs) and Institutional Development Award (IDeA)-eligible institutions for scaled production and distribution of brain cell type-specific access reagents. The reagents to be distributed will first be developed in separately supported reagent design and development projects for brain cell type-specific access across vertebrate species in the BRAIN Initiative Armamentarium project. Recipients of awards under this NOFO will then work with these Armamentarium projects to manufacture and distribute the reagents for use throughout the neuroscience community. It is envisioned that the recipients will work both with Armamentarium researchers as well as with the neuroscience research community to optimize the new reagents. The types of reagents to be produced and distributed could include but are not limited to viral vectors, nucleic acid constructs, and nanoparticles designed for selective access to brain cell types. Such reagents will enable neuroscientists to probe circuit function with high precision in experimental animals and ex vivo human tissue and cells. Facilities are needed to contribute to the production and distribution of BRAIN Initiative Armamentarium project reagents broadly to neuroscience users. This NOFO is part of the BRAIN Initiative Armamentarium project, whose overall goal is to generate tools to specifically access, manipulate, and monitor brain cell types across multiple vertebrate species. This NOFO will foster close interaction between technologists, disseminators, and neurobiologists in a research consortium including investigators funded by other Armamentarium NOFOs.

Deadlines:

Letter of Intent Due Date(s): 30 days prior to the application due date
Application Due Date(s): Feb. 14, 2025; Feb. 2, 2026; June 15, 2027

RFA-MH-26-120 Expiration Date June 16, 2027

Specialties

Engineering and Physical Sciences

Medical

Medical - Clinical Science

Interdisciplinary

Medical - Basic Science

Eligibility Requirements

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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