The Advanced Research Projects Agency for Health (ARPA-H) is posting this DRAFT Innovative Solutions Opening (ISO) ARPA-H-SOL-24-111 for the Groundbreaking Lymphatic Interventions and Drug Exploration (GLIDE) Program in order to help potential proposers prepare for Proposer's Day and plan for solution summary submission.
The finalized ISO and related attachments will be posted at a later date.
The GLIDE program envisions a future where doctors will have a therapeutic armamentarium targeting abnormal lymphatic structure and function, dramatically expanding the role of the lymphatic system, not only for primary lymphatic diseases but in the treatment of all chronic diseases. The program will develop therapeutic and physical interventions that alleviate, repair, and regenerate irregular or dysfunctional lymphatic vasculature, while including product design and commercialization considerations that favor broad accessibility and adoption by the community of hospitals, healthcare providers, and patients.
Today, patients with a primary lymphatic disease (LD) or a common chronic disease with underlying lymphatic dysfunction must manage often progressive and debilitating lifethreatening symptoms for their entire life. Existing therapies are very limited and almost exclusively palliative.
GLIDE will develop a variety of treatment options available for patients that address the underlying mechanisms of lymphatic dysfunction; either curing the disease state or safely stabilizing the disease and providing significant relief.
Response Date: Oct. 31, 2024
Sponsor Institute/Organizations: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
Oct 31, 2024
Varies
Affiliation: National Institutes of Health
Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA
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