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Aging Mammalian Tissues In Vitro

National Institutes of Health

Note: This is a Forecasted Opportunity.

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that propose interdisciplinary research that aims to develop complex mammalian 3-dimensional (3D) in vitro microphysiological systems (MPS) to model aging and recapitulate aging processes/phenotypes observed in the whole organism in vivo. It is anticipated that the NOFO will primarily focus on human cell-derived MPS (e.g., tissue chip, organ-on-chip, tissue organoids). However, systems developed using cells of nonhuman mammalian origin may be acceptable for benchmarking, system validation, or when their relevance to understanding human aging biology is justified. Projects will be expected to advance the adoption of MPS in aging biology research and as new human-relevant tools for drug discovery.

It is anticipated that the NOFO will support exploratory research at the early and conceptual stages of project development. Preliminary data will not be required. It is anticipated that an essential feature of responsive applications will be the adoption of a multidisciplinary approach that includes expertise in aging biology and from disciplines such as stem cell biology, tissue and organ physiology, microfluidics, bioengineering, computational biology, pharmacology, and biostatistics.

Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

Estimated Post Date:

Aug 15, 2025

Estimated Application Due Date:

Oct 15, 2025

Specialties

Interdisciplinary

Medical - Basic Science

Medical - Translational

Medical

Medical - Clinical Science

Eligibility Requirements

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Sponsor Type: Government/Federal

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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