Trialect

Active

Call for proposals-Molecular glue degraders and other PPI stabilisers

Merck

This grant provides financial support for research initiatives that concentrate on pioneering novel approaches for the screening & discovery of molecular glues.

Molecular glues are small molecules capable of inducing proximity between a target protein and an effector protein inside the cells, hence relying on the effector protein to elicit target protein function. Molecular glues have been discovered, that lead to degradation (e.g. IMIDs), inhibition (e.g. cyclosporin A)or activation of the target protein (asukamycin).

Targeting proteins via the molecular glue mechanism holds the promise to tackle non-ligandable proteins that are considered “non-druggable". However, the identification of degraders or other proximity inducers utilizing this mode of action for specific proteins has historically been largely serendipitous [1].

We are committed to providing financial support for research initiatives that concentrate on pioneering novel approaches for the screening and discovery of molecular glues.

Specialties

Molecular Biology

Eligibility Requirements

All research initiatives that concentrate on pioneering novel approaches for the screening and discovery of molecular glues are supported.

Sponsor Details

Sponsor Institute/Organizations: Merck

Address: Merck, Darmstadt, Germany

View Funding Opportunity

Grant

Letter Of Intent Deadline:

Sep 22, 2024

Final Deadline:

Sep 22, 2024

Funding Amount:

$110,945

Questions and Answers

Commonly asked questions about this funding opportunity from the host and other attendees.

How do I apply?

In order to apply, fill out the application form with your research proposal, using non-confidential information only. Please make sure you have read and accepted the terms and conditions before you submit the application form.

Are there any requirements for the attachments I can submit in addition to the abstract?

During the first phase of the application process, we only require title, abstract and information on the project team. Additionally, you can add documents and graphics that explain the concept. There are no formal requirements for the attachments, most commonly used formats will work (for example, pdf or ppt). Please do not include any confidential information at this stage. Get in touch with us in case you have issues uploading documents to the submissions portal on researchgrants@merckgroup.com.

Can I send in my application for more than one focus topic?

Yes, you should apply for those research topics that are relevant to your proposal and you may submit multiple applications.

My proposal fits well to the topic description but not sure that it addresses all aspects.

We only will disqualify proposals that fall entirely outside the scope of the grant description. Eligible proposals will be evaluated based on the criteria subject to the research grants terms and conditions. These are currently innovativeness, commercial potential, path forward after 3 years, probability of success, team strength, strategic fit.

When will the research grants be paid out?

Following the Deep Dive workshops, Merck enters into bilateral collaboration agreements with the winning recipients to enable pay-out and project start. During the collaboration, there will be regular meetings with Merck scientists.