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Breast Cancer Research Program Breakthrough Award Levels 1 and 2

Congressionally Directed Medical Research Programs

Supports promising research that has high potential to lead to or make breakthroughs in breast cancer. All applications must address at least one of the fiscal year 2025 (FY25) Breast Cancer Research Program (BCRP) overarching challenges, unless adequate justification for exception is provided. Applications must address the challenge in a way that can lead to or make a breakthrough and have major impact. The FY25 Breakthrough Award mechanism contains three different funding levels designed to support major (but not all) stages of research that will lead to clinical application. Each level has a defined research scope. The current program announcement discusses the Breakthrough Award Levels 1 and 2.

Funding Details:

The Congressionally Directed Medical Research Programs (CDMRP) expects to allot approximately $37.7 million (M) to fund approximately 20 Breakthrough Award Levels 1 and 2 applications with direct cost caps of $0.54M (single PI) or $0.9M (PPIO) for Funding Level 1, $1.2M (single PI) or $1.8M (PPIO) for Funding Level 2, or $1.8M (single PI) or $2.4M (PPIO) for Funding Level 2 - Population Science and Prevention Studies. The maximum period of performance is three years for Breakthrough Award Funding Levels 1 and 2 and four years for Breakthrough Award Level 2 – Population Science and Prevention Studies. It is anticipated that awards made from this FY25 funding opportunity will be funded with FY25 funds, which will expire for use on September 30, 2031. Awards supported with FY25 funds will be made no later than September 30, 2026.

Specialties

Cancer

General Medicine

Clinical Trials

Oncology

Eligibility Requirements

Organization

Extramural and intramural organizations are eligible to apply, including foreign and domestic organizations, for-profit and nonprofit organizations, and public or private entities.

Extramural Organization: An eligible non-Department of Defense (DOD) organization. Examples of extramural organizations include academic institutions, biotechnology companies, foundations, federal government organizations other than the DOD (i.e., intragovernmental organizations), and research institutes.

Intramural DOD Organization: Refers specifically to DOD organizations including DOD laboratories, DOD military treatment facilities, and/or DOD activities embedded within a civilian medical center

Principal Investigator

Investigators at all academic levels (or equivalent) are eligible to be named as a PI, Initiating PI, or Partnering PI on an application.

Applications are encouraged for postdoctoral fellows. A Mentorship Statement (Attachment 9) is required for applications submitted with a PI who is a postdoctoral fellow.

Each investigator may be named as a PI or Initiating PI on only one application per funding level for this Breakthrough Award Levels 1 and 2 program announcement.

There are no limitations on the number of applications for which an investigator may be named as a Partnering PI. To meet the intent of the Partnering PI Option, investigators are discouraged from being named as a Partnering PI on multiple Breakthrough Award Levels 1 and 2 applications unless they are clearly unique, meaningful partnerships addressing distinct research questions.

Applications must include a brief description of all the applications in which the investigator is named as a PI, Initiating PI, Partnering PI, collaborator, or mentor under this Breakthrough Award Levels 1 and 2 program announcement. Individuals affiliated with an eligible organization are eligible to be named as PI regardless of ethnicity, nationality, or citizenship status.

Sponsor Details

Sponsor Institute/Organizations: Congressionally Directed Medical Research Programs

Sponsor Type: Corporate/Non-Profit

Address: Fort Detrick Frederick, MD 21702

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