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Breast Cancer Research Program Breakthrough Award Level 3

Congressionally Directed Medical Research Programs

Supports promising research that has high potential to lead to or make breakthroughs in breast cancer. All applications must address at least one of the fiscal year 2025 (FY25) Breast Cancer Research Program (BCRP) overarching challenges, unless adequate justification for exception is provided. Applications must address the challenge in a way that can lead to or make a breakthrough and have major impact. The FY25 Breakthrough Award mechanism contains three different funding levels designed to support major (but not all) stages of research that will lead to clinical application. Each level has a defined research scope. The current program announcement discusses the Breakthrough Award Level 3.

Funding Details:

The Congressionally Directed Medical Research Programs (CDMRP) expects to allot approximately $27.9 million (M) to fund approximately three Breakthrough Award Level 3 applications with direct cost caps of $4M for applications with a single PI or $5M if applying under the PPIO. The maximum period of performance is four years. It is anticipated that awards made from this FY25 funding opportunity will be funded with FY25 funds, which will expire for use on September 30, 2031. Awards supported with FY25 funds will be made no later than September 30, 2026.

Submission and Review Dates and Times

• Pre-Application (Preproposal) Submission Deadline: 5:00 p.m. Eastern Time (ET), June 13, 2025

• Invitation to Submit an Application: July 18, 2025

• Application Submission Deadline: 11:59 p.m. ET, September 10, 2025

• End of Application Verification Period: 5:00 p.m. ET, September 15, 2025

• Peer Review: November 2025

• Programmatic Review: January 2026

Announcement Type: Initial

Funding Opportunity Number: HT942525BCRPBTA3

Assistance Listing Number: 12.420

Specialties

Cancer

Clinical Trials

Eligibility Requirements

Organization

Extramural and intramural organizations are eligible to apply, including foreign and domestic organizations, for-profit and nonprofit organizations, and public or private entities.

Extramural Organization: An eligible non-Department of Defense (DOD) organization. Examples of extramural organizations include academic institutions, biotechnology companies, foundations, federal government organizations other than the DOD (i.e., intragovernmental organizations), and research institutes.

Intramural DOD Organization: Refers specifically to DOD organizations including DOD laboratories, DOD military treatment facilities, and/or DOD activities embedded within a civilian medical center.

Principal Investigator

Independent investigators at all academic levels (or equivalent) are eligible to be named as a PI, Initiating PI, or Partnering PI on an application.

There are no limits on the number of pre-applications an investigator may submit as a PI, Initiating PI, or Partnering PI for this Breakthrough Award Level 3 program announcement. Investigators are discouraged from being named on multiple pre-applications unless they are clearly addressing distinct research questions. Invited applications must include a brief description of all the applications in which the investigator is named as a PI, Initiating PI, Partnering PI, or collaborator under this Breakthrough Award Level 3 program announcement.

Individuals affiliated with an eligible organization are eligible to be named as PI regardless of ethnicity, nationality, or citizenship status.

Sponsor Details

Sponsor Institute/Organizations: Congressionally Directed Medical Research Programs

Sponsor Type: Corporate/Non-Profit

Address: Fort Detrick Frederick, MD 21702

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