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American Cancer Society and Flatiron Clinical Trials Technology Research Impact Award (CTTRIA)

American Cancer Society

The Clinical Trials Technology Research Impact Award (CTTRIA) supports a shared goal of the American Cancer Society (ACS) and Flatiron to accelerate cancer research by improving access, representativeness, and efficiency of clinical trials, ultimately accelerating the development of new treatments to benefit patients.

Scientific Scope

Clinical trials provide patients access to emerging cancer treatments that may be more effective than existing treatments, while advancing research for future generations of patients. However, there are several challenges to the efficient conduct of clinical trials, including the ever-present burden of data capture. The volume of study data is often overwhelming and challenging to manage for study teams as data entry can be repetitive, burdensome, and error-prone.

This Request for Applications (RFA) is a call for investigators to propose ways to implement, utilize, and/or study the impact of technology to advance the conduct of cancer clinical trials. Electronic Health Record-to-Electronic Data Collection (EHR-to-EDC) software is an emerging innovation that facilitates the automated transfer of data directly from the EHR source to clinical trial research databases, reducing the inefficiency and errors associated with manual data entry.

One such tool is Flatiron Clinical PipeTM—an EHR-embedded EHR-to-EDC solution—that enables transfer of structured study data using Fast Healthcare Interoperability Resources (FHIR). In addition, it provides electronic forms that are accessible within the tool to enable tracking and transfer of data required for clinical trials such as adverse events or tumor measurements.

The goal of this RFA is to investigate how interoperable technology affects the efficiency and conduct of cancer clinical trials.

Projects must include the use of Clinical PipeTM to transfer study data for one or more trials (sponsored or investigator-initiated); this grant will not support the trials themselves. Special consideration will be given to multi-institutional projects/studies at sites that do not currently have the EHR-to-EDC connector Flatiron Clinical PipeTM installed. Flatiron will assist in tech installation, if needed, at participating sites.

Examples of possible research projects for this funding mechanism are listed below.

Analyzing the impact of electronic data transfer on research staff effort, time needed for data entry, productivity, and/or staff satisfaction
Assessing the impact of EHR-to-EDC technology on the quality of data entry, timeliness of data entry, data accuracy and completeness, and/or queries issued
Modeling the impact of EHR-to-EDC technology on study timelines and overall cost
Evaluating the feasibility of deployment of EHR-to-EDC software for a multi-institutional investigator-initiated cancer trial
Developing a change management guide for migration from paper to electronic workflows for research data capture

The ultimate goal in improving the efficiency and data capture of cancer clinical trials is to better evaluate new treatments, increase the accessibility of studies for patients, and promote better health outcomes for all patients.

Specialties

Cancer

Oncology

Clinical Trials

Others

Eligibility Requirements

Eligible applicants must be independent researchers at an eligible academic institution or nonprofits in the United States. Applicants must have the necessary training and expertise to conduct research. All applicants shall be subject to the terms and conditions of a separate confidentiality agreement with Flatiron.

Eligible Countries:

United States

Sponsor Details

Sponsor Institute/Organizations: American Cancer Society

Sponsor Type: Corporate/Non-Profit

Address: 270 Peachtree St NW, Suite 1300 Atlanta , GA 30303

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